منابع مشابه
Triplet photosensitization and the photobiology of thymine dimers in DNA.
The knowledge of the energy levels of the lowest triplet states of the DNA constituents obtained from photophysical experiments has allowed the design of a photochemical technique which introduces a specific change in the DNA structure, the dimerization of adjacent thymine residues, which, in turn, has led to important conclusions about the role of thymine dimers in the u.v. photobiology of T4 ...
متن کاملThymine Dimers - Dna Lesions Induced by Sunlight Cis-syn Thymine Dimer Phosphoramidite Now Available
3900 COLUMNS One of the major sources of DNA damage in all organisms is the UV component of sunlight. The predominant reaction induced by UV light on DNA is dimerization of adjacent pyrimidine bases leading to cyclobutane dimers (CPDs) and 6-4 photoproducts. The dimers formed in the most significant quantity are the cis-syn cyclobutane dimer of two thymine bases (1) and the corresponding 64 pho...
متن کاملEvidence that ultraviolet-induced thymine dimers in DNA cause biological damage.
6 Lengyel, P., J. F. Speyer, C. Basilio, and S. Ochoa, these PROCEEDINGS, 48, 282 (1962). 6 Speyer, J. F., P. Lengyel, C. Basilio, and S. Ochoa, these PROCEEDINGS, 48, 441 (1962). 7 Matthaei, J. H., 0. W. Jones, R. G. Martin, and M. W. Nirenberg, these PROCEEDINGS, 48, 666 (1962). 8 Crick, F. H. C., L. Barnett, S. Brenner, and R. J. Watts-Tobin, Nature, 192, 1227 (1961). 9 Smith, E. L., these P...
متن کاملPhotosensitized formation of thymine dimers in DNA by tyramine, tyrosine and tyrosine-containing peptides.
The formation of Thy-Thy in DNA in the presence of tyramine, tyrosine and tyrosine-containing peptides such as Lys-Tyr and Lys-Tyr-Lys was studied with monochromatic UV irradiation. The formation of Thy-Thy by UV irradiation was enhanced in the presence of these compounds. The action spectrum of the photosensitization has a peak near 280 nm corresponding to the absorption spectrum of tyrosine. ...
متن کاملA deoxyribozyme that harnesses light to repair thymine dimers in DNA.
In vitro selection was used to investigate whether nucleic acid enzymes are capable of catalyzing photochemical reactions. The reaction chosen was photoreactivation of thymine cyclobutane dimers in DNA by using serotonin as cofactor and light of wavelengths longer than the absorption spectrum of DNA. Curiously, the dominant single-stranded DNA sequence selected, UV1A, was found to repair its in...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.8.2558